Rational Approaches to Improving Selectivity in Drug Design 论文

摘要

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTRational Approaches to Improving Selectivity in Drug DesignDavid J. Huggins*†‡, Woody Sherman*§, and Bruce Tidor*∥⊥#View Author Information† Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Hills Road, Cambridge, CB2 0XZ, United Kingdom‡ Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom§ Schrödinger Inc., 120 West 45th Street, New York, New York 10036, United States∥Computer Science and Artificial Intelligence Laboratory, ⊥Department of Biological Engineering, and #Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States*For D.J.H.: phone, +44 1223 763367; fax, +44 1223 763 374; e-mail, [email protected]. For W.S.: phone, +1 212 295 5800; fax, +1 212 295 5801; e-mail, [email protected]. For B.T.: phone, +1 617 253 7258; fax, +1 617 252 1816; e-mail, [email protected]Cite this: J. Med. Chem. 2012, 55, 4, 1424–1444Publication Date (Web):January 12, 2012Publication History Received2 August 2011Published online12 January 2012Published inissue 23 February 2012https://doi.org/10.1021/jm2010332Copyright © 2012 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views26263Altmetric-Citations174LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (9 MB) Get e-AlertsSUBJECTS:Inhibitors,Peptides and proteins,Selectivity,Receptors,Molecules Get e-Alerts