Paramyxovirus RNA Synthesis and the Requirement for Hexamer Genome Length: the Rule of Six Revisited 论文

摘要

The template for paramyxovirus RNA synthesis is not naked RNA but the helical nucleocapsid core of the virus, in which each nucleocapsid protein (N protein) is predicted to be associated with precisely 6 nucleotides (nt) (11). Presumably as a consequence of this association, paramyxovirus genomes are replicated efficiently only when they are a multiple of 6 nt in length, and this has been dubbed the “rule of six” (4). The structure of paramyxovirus nucleocapsids is thus central to understanding how this rule might operate.