MedCollab: IBIS-Guided Multi-Agent Collaboration with Hierarchical Disease Relation Chains for Clinical Diagnosis 文章

arXiv:2603.01131v2 Announce Type: replace-cross Abstract: Large language models (LLMs) have shown promise in clinical diagnosis but remain limited by unreliable report generation, weak evidence grounding, and opaque reasoning. We propose MedCollab, an IBIS-guided multi-agent framework for full-cycle clinical diagnosis and diagnostic report generation. Mimicking hospital consultation, MedCollab dynamically recruits specialist and exam agents from patient records. Each diagnostic hypothesis is structured through the Issue-Based Information System (IBIS) into evidence-linked arguments, improving traceability and auditability. MedCollab further constructs Hierarchical Disease Relation Chains (HDRC) to organize accepted hypotheses into clinically meaningful pathological and comorbidity relations. A verifier-guided consensus module audits reasoning quality, detects contradictions, and updates agent weights over multiple rounds.