Beyond Prompt-Based Planning: MCP-Native Graph Planning-based Biomedical Agent System 文章

arXiv:2606.04494v1 Announce Type: new Abstract: Biomedical agents promise to automate complex biological workflows, yet current systems face two fundamental bottlenecks: bioinformatics tools are highly heterogeneous in interfaces and execution environments, while agent planning still relies on flat prompt-retrieved tool descriptions. As biomedical software ecosystems grow, this coupling between tool coverage and context size leads to tool confusion, unstable planning, and inefficient execution. We introduce BioManus, an MCP-native biomedical agent built on graph-scaffolded planning over structured biological capabilities. BioManus first introduces the BioinfoMCP Compiler, which converts heterogeneous bioinformatics software into standardized MCP servers, yielding a large executable MCP ecosystem. It then organizes this ecosystem as a typed heterogeneous MCP graph over tools, operations, datatypes, and workflow stages.