ProHiFlo: Hierarchical Flow Matching with Functional Guidance for De Novo Protein Generation 事件

ProHiFlo: Hierarchical Flow Matching with Functional Guidance for De Novo Protein Generation arXiv:2606.11243v1 Announce Type: cross Abstract: De novo protein generation has transformative potential in therapeutic design, enzyme engineering, and synthetic biology. While diffusion-based and flow matching approaches have achieved progress, they typically operate at single resolution and lack mechanisms for incorporating functional constraints. We introduce ProHiFlo, a hierarchical flow matching f