SurfDesign: Effective Protein Design on Molecular Surfaces 事件

SurfDesign: Effective Protein Design on Molecular Surfaces arXiv:2606.07567v1 Announce Type: cross Abstract: Protein function is largely determined by molecular surface geometry and physicochemical complementarity, yet most protein design methods condition only on backbone structure. We introduce SurfDesign, a surface-conditioned protein design framework that models molecular surfaces as continuous geometric manifolds and integrates them with pretrained protein language models. SurfDesign emplo