Does a ‘volume-filling effect’ always prevent chemotactic collapse? 论文

2009Mathematical Methods in the Applied Sciences引用 317
Mathematical Biology Tumor GrowthGene Regulatory Network AnalysisAdvanced Mathematical Modeling in Engineering

摘要

The parabolic–parabolic Keller–Segel system for chemotaxis phenomena, is considered under homogeneous Neumann boundary conditions in a smooth bounded domain Ω⊂ℝn with n⩾2. It is proved that if ψ(u)/ϕ(u) grows faster than u2/n as u→∞ and some further technical conditions are fulfilled, then there exist solutions that blow up in either finite or infinite time. Here, the total mass ∫Ωu(x, t)dx may attain arbitrarily small positive values. In particular, in the framework of chemotaxis models incorporating a volume-filling effect in the sense of Painter and Hillen (Can. Appl. Math. Q. 2002; 10(4):501–543), the results indicate how strongly the cellular movement must be inhibited at large cell densities in order to rule out chemotactic collapse. Copyright © 2009 John Wiley & Sons, Ltd.