Mechanism-Based Target Identification and Drug Discovery in Cancer Research 论文
2000Science引用 610
Ubiquitin and proteasome pathwaysComputational Drug Discovery MethodsProtein Degradation and Inhibitors
详细信息
- 发表期刊/会议
- Science
- 发表日期
- 2000-03-17
- 发表年份
- 2000
关键词
Ubiquitin and proteasome pathwaysComputational Drug Discovery MethodsProtein Degradation and Inhibitors
摘要
Cancer as a disease in the human population is becoming a larger health problem, and the medicines used as treatments have clear limitations. In the past 20 years, there has been a tremendous increase in our knowledge of the molecular mechanisms and pathophysiology of human cancer. Many of these mechanisms have been exploited as new targets for drug development in the hope that they will have greater antitumor activity with less toxicity to the patient than is seen with currently used medicines. The fruition of these efforts in the clinic is just now being realized with a few encouraging results.