Extended monod kinetics for substrate, product, and cell inhibition 论文
1988Biotechnology and Bioengineering引用 367
Gene Regulatory Network AnalysisComputational Drug Discovery MethodsMathematical Biology Tumor Growth
详细信息
- 发表期刊/会议
- Biotechnology and Bioengineering
- 发表日期
- 1988-08-05
- 发表年份
- 1988
关键词
Gene Regulatory Network AnalysisComputational Drug Discovery MethodsMathematical Biology Tumor Growth
摘要
A generalized form of Monod kinetics is proposed to account for all kinds of product, cell, and substrate inhibition. This model assumes that there exists a critical inhibitor concentration above which cells cannot grow, and that the constants of the Monod equation are functions of this limiting inhibitor concentration. Methods for evaluating the constants of this rate form are presented. Finally the proposed kinetic form is compared with the available data in the literature, which unfortunately is very sparse. In all cases, this equation form fitted the data very well.