Three-Dimensional Pharmacophore Methods in Drug Discovery 论文

摘要

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTThree-Dimensional Pharmacophore Methods in Drug DiscoveryAndrew R. Leach*∥, Valerie J. Gillet§, Richard A. Lewis‡, and Robin Taylor†View Author Information∥ Computational and Structural Chemistry, GlaxoSmithKline Research & Development, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.§ Department of Information Studies, University of Sheffield, Regent Court, 211 Portobello Street, Sheffield S1 4DP, U.K.‡ Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland† Taylor Cheminformatics Software, 54 Sherfield Avenue, Rickmansworth, Herts WD3 1NL, U.K.*To whom correspondence should be addressed. Phone: +44 1438 763383. Fax: +44 1438 763352. E-mail [email protected]Cite this: J. Med. Chem. 2010, 53, 2, 539–558Publication Date (Web):October 15, 2009Publication History Received5 June 2009Published online15 October 2009Published inissue 28 January 2010https://pubs.acs.org/doi/10.1021/jm900817uhttps://doi.org/10.1021/jm900817ureview-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views10657Altmetric-Citations290LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Conformation,Drug discovery,Ligands,Molecules,Pharmacophores Get e-Alerts