Hepatotoxicity with Combination of Vemurafenib and Ipilimumab 论文
2013New England Journal of Medicine引用 701
Melanoma and MAPK PathwaysCutaneous Melanoma Detection and ManagementComputational Drug Discovery Methods
详细信息
- 发表期刊/会议
- New England Journal of Medicine
- 发表日期
- 2013-04-03
- 发表年份
- 2013
关键词
Melanoma and MAPK PathwaysCutaneous Melanoma Detection and ManagementComputational Drug Discovery Methods
摘要
The independent mechanisms of action and largely nonoverlapping toxicity profiles of vemurafenib and ipilimumab made it logical to test them together in a study of patients with melanoma. An unexpected level of hepatic toxicity caused the early termination of the study.