Sorting Permutations by Reversals and Eulerian Cycle Decompositions 论文

1999SIAM Journal on Discrete Mathematics引用 227
Genome Rearrangement AlgorithmsAlgorithms and Data CompressionDNA and Biological Computing

摘要

We analyze the strong relationship among three combinatorial problems, namely, the problem of sorting a permutation by the minimum number of reversals (MIN-SBR), the problem of finding the maximum number of edge-disjoint alternating cycles in a breakpoint graph associated with a given permutation (MAX-ACD), and the problem of partitioning the edge set of an Eulerian graph into the maximum number of cycles (MAX-ECD). We first illustrate a nice characterization of breakpoint graphs, which leads to a linear-time algorithm for their recognition. This characterization is used to prove that MAX-ECD and MAX-ACD are equivalent, showing the latter to be NP-hard. We then describe a transformation from MAX-ACD to MIN-SBR, which is therefore shown to be NP-hard as well, answering an outstanding question which has been open for some years. Finally, we derive the worst-case performance of a well-known lower bound for MIN-SBR, obtained by solving MAX-ACD, discussing its implications on approximation algorithms for MIN-SBR.