Allosteric Mechanisms of Signal Transduction 论文

详细信息

发表期刊/会议

Science

发表日期

2005-06-02

发表年份

2005

摘要

Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation.