Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network 论文
2009Genome biology引用 236顶会
Bioinformatics and Genomic NetworksComputational Drug Discovery MethodsGenetic Associations and Epidemiology
详细信息
- 发表期刊/会议
- Genome biology
- 发表日期
- 2009-09-03
- 发表年份
- 2009
关键词
Bioinformatics and Genomic NetworksComputational Drug Discovery MethodsGenetic Associations and Epidemiology
摘要
We integrate 16 genomic features to construct an evidence-weighted functional-linkage network comprising 21,657 human genes. The functional-linkage network is used to prioritize candidate genes for 110 diseases, and to reliably disclose hidden associations between disease pairs having dissimilar phenotypes, such as hypercholesterolemia and Alzheimer's disease. Many of these disease-disease associations are supported by epidemiology, but with no previous genetic basis. Such associations can drive novel hypotheses on molecular mechanisms of diseases and therapies.