Alzheimer's Disease Is a Synaptic Failure 论文

详细信息

发表期刊/会议

Science

发表日期

2002-10-24

发表年份

2002

摘要

In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid beta protein.