Iterative random forests to discover predictive and stable high-order interactions 论文

详细信息

发表期刊/会议

Proceedings of the National Academy of Sciences

发表日期

2018-01-19

发表年份

2018

摘要

), suggest high-order relationships that are candidates for follow-up experiments. In human-derived cells, iRF rediscovered a central role of H3K36me3 in chromatin-mediated splicing regulation and identified interesting fifth- and sixth-order interactions, indicative of multivalent nucleosomes with specific roles in splicing regulation. By decoupling the order of interactions from the computational cost of identification, iRF opens additional avenues of inquiry into the molecular mechanisms underlying genome biology.