[{"_1":2,"_3":-5,"_4":-5},"loaderData",{"_5":6,"_7":8,"_9":10},"actionData","errors","root",{"_477":478},"routes/_layout",{"_11":397},"routes/entity.$type.$id",{"_11":12,"_13":14,"_15":16,"_17":18,"_19":20,"_21":22,"_23":24,"_25":26,"_27":28},"dehydratedState",{"_73":74,"_75":76},"type","paper","id","paper_W3131767541","section","authors","entity",{"_15":16,"_29":30,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":38,"_39":-5,"_40":41,"_42":43,"_44":45,"_46":47,"_48":-5,"_49":50,"_51":30,"_52":53,"_54":55,"_56":57,"_58":59,"_60":61,"_18":-5,"_62":63,"_64":65,"_66":67,"_68":30,"_69":-5},"canonical","https://www.hugmap.com/entity/paper/paper_W3131767541/authors","siteBaseUrl","https://www.hugmap.com","sectionCount",33,"jsonLd","{\"@context\":\"https://schema.org\",\"@graph\":[{\"name\":\"SARS-CoV-2 M ^pro inhibitors with antiviral activity in a transgenic mouse model\",\"url\":\"https://www.hugmap.com/entity/paper/paper_W3131767541/authors\",\"@type\":\"ScholarlyArticle\",\"headline\":\"SARS-CoV-2 M ^pro inhibitors with antiviral activity in a transgenic mouse model\",\"datePublished\":\"2021-02-18\",\"isPartOf\":{\"@type\":\"Periodical\",\"name\":\"Science\"}},{\"@type\":\"CollectionPage\",\"name\":\"SARS-CoV-2 M ^pro inhibitors with antiviral activity in a transgenic mouse model 作者\",\"description\":\"SARS-CoV-2 M ^pro inhibitors with antiviral activity in a transgenic mouse model 在 HugMap 中的作者，共 33 条，含结构化关联信息与详情链接。\",\"url\":\"https://www.hugmap.com/entity/paper/paper_W3131767541/authors\",\"inLanguage\":\"zh-CN\"},{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"首页\",\"item\":\"https://www.hugmap.com/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"论文\",\"item\":\"https://www.hugmap.com/search?type=paper\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"SARS-CoV-2 M ^pro inhibitors with antiviral activity in a transgenic mouse model\",\"item\":\"https://www.hugmap.com/entity/paper/paper_W3131767541\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"作者\",\"item\":\"https://www.hugmap.com/entity/paper/paper_W3131767541/authors\"}]}]}","name","SARS-CoV-2 M ^pro inhibitors with antiviral activity in a transgenic mouse model","nameZh","aliases","description","descriptionZh","status","active","externalIds","{\"openalex\":\"W3131767541\",\"doi\":\"10.1126/science.abf1611\"}","properties","source","openalex","createdAt","2026-05-16T14:05:54.224113193","updatedAt","2026-05-19T06:45:56.184860174","doi","10.1126/science.abf1611","arxivId","openalexId","W3131767541","title","abstractText","in complex with MI-23, one of the most potent compounds, revealed its interaction mode. Two compounds (MI-09 and MI-30) showed excellent antiviral activity in cell-based assays. In a transgenic mouse model of SARS-CoV-2 infection, oral or intraperitoneal treatment with MI-09 or MI-30 significantly reduced lung viral loads and lung lesions. Both also displayed good pharmacokinetic properties and safety in rats.","publishedDate","2021-02-18","publishedYear",2021,"venue","Science","citationCount",448,"keywords",[70,71,72],"pdfUrl","https://bib-pubdb1.desy.de/record/471682","topVenue",false,"displayName","displayDescription","SARS-CoV-2 and COVID-19 Research","Computational Drug Discovery Methods","Viral gastroenteritis research and epidemiology","mutations",[],"queries",[77],{"_78":79,"_80":81,"_82":83,"_84":85},"dehydratedAt",1780898661459,"state",{"_87":88,"_89":90,"_91":79,"_92":-5,"_93":94,"_95":94,"_96":94,"_97":-5,"_98":-5,"_99":67,"_35":100,"_101":102},"queryKey",[86,19,14,16],"queryHash","[\"portal\",\"entity\",\"paper\",\"paper_W3131767541\"]","portal","data",{"_19":20,"_103":104,"_105":106,"_107":108,"_109":110,"_111":112,"_18":113},"dataUpdateCount",1,"dataUpdatedAt","error","errorUpdateCount",0,"errorUpdatedAt","fetchFailureCount","fetchFailureReason","fetchMeta","isInvalidated","success","fetchStatus","idle","entityType","Paper","taxonomies",[365,366,367],"events",[],"articles",[],"technologies",[350],[114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146],{"_15":344,"_29":345,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":346,"_39":-5,"_40":41,"_42":347,"_44":348,"_152":349,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":345,"_69":-5},{"_15":338,"_29":339,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":340,"_39":-5,"_40":41,"_42":341,"_44":342,"_152":343,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":339,"_69":-5},{"_15":332,"_29":333,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":334,"_39":-5,"_40":41,"_42":335,"_44":336,"_152":337,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":333,"_69":-5},{"_15":326,"_29":327,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":328,"_39":-5,"_40":41,"_42":329,"_44":330,"_152":331,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":327,"_69":-5},{"_15":320,"_29":321,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":322,"_39":-5,"_40":41,"_42":323,"_44":324,"_152":325,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":321,"_69":-5},{"_15":314,"_29":315,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":316,"_39":-5,"_40":41,"_42":317,"_44":318,"_152":319,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":315,"_69":-5},{"_15":308,"_29":309,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":310,"_39":-5,"_40":41,"_42":311,"_44":312,"_152":313,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":309,"_69":-5},{"_15":302,"_29":303,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":304,"_39":-5,"_40":41,"_42":305,"_44":306,"_152":307,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":303,"_69":-5},{"_15":296,"_29":297,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":298,"_39":-5,"_40":41,"_42":299,"_44":300,"_152":301,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":297,"_69":-5},{"_15":290,"_29":291,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":292,"_39":-5,"_40":41,"_42":293,"_44":294,"_152":295,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":291,"_69":-5},{"_15":284,"_29":285,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":286,"_39":-5,"_40":41,"_42":287,"_44":288,"_152":289,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":285,"_69":-5},{"_15":278,"_29":279,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":280,"_39":-5,"_40":41,"_42":281,"_44":282,"_152":283,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":279,"_69":-5},{"_15":272,"_29":273,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":274,"_39":-5,"_40":41,"_42":275,"_44":276,"_152":277,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":273,"_69":-5},{"_15":266,"_29":267,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":268,"_39":-5,"_40":41,"_42":269,"_44":270,"_152":271,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":267,"_69":-5},{"_15":260,"_29":261,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":262,"_39":-5,"_40":41,"_42":263,"_44":264,"_152":265,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":261,"_69":-5},{"_15":255,"_29":256,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":257,"_39":-5,"_40":41,"_42":258,"_44":259,"_152":-5,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":256,"_69":-5},{"_15":249,"_29":250,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":251,"_39":-5,"_40":41,"_42":252,"_44":253,"_152":254,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":250,"_69":-5},{"_15":244,"_29":245,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":246,"_39":-5,"_40":41,"_42":247,"_44":248,"_152":-5,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":245,"_69":-5},{"_15":238,"_29":239,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":240,"_39":-5,"_40":41,"_42":241,"_44":242,"_152":243,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":239,"_69":-5},{"_15":233,"_29":234,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":235,"_39":-5,"_40":41,"_42":236,"_44":237,"_152":-5,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":234,"_69":-5},{"_15":227,"_29":228,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":229,"_39":-5,"_40":41,"_42":230,"_44":231,"_152":232,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":228,"_69":-5},{"_15":221,"_29":222,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":223,"_39":-5,"_40":41,"_42":224,"_44":225,"_152":226,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":222,"_69":-5},{"_15":215,"_29":216,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":217,"_39":-5,"_40":41,"_42":218,"_44":219,"_152":220,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":216,"_69":-5},{"_15":209,"_29":210,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":211,"_39":-5,"_40":41,"_42":212,"_44":213,"_152":214,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":210,"_69":-5},{"_15":203,"_29":204,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":205,"_39":-5,"_40":41,"_42":206,"_44":207,"_152":208,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":204,"_69":-5},{"_15":197,"_29":198,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":199,"_39":-5,"_40":41,"_42":200,"_44":201,"_152":202,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":198,"_69":-5},{"_15":191,"_29":192,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":193,"_39":-5,"_40":41,"_42":194,"_44":195,"_152":196,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":192,"_69":-5},{"_15":185,"_29":186,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":187,"_39":-5,"_40":41,"_42":188,"_44":189,"_152":190,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":186,"_69":-5},{"_15":180,"_29":181,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":182,"_39":-5,"_40":41,"_42":183,"_44":184,"_152":-5,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":181,"_69":-5},{"_15":174,"_29":175,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":176,"_39":-5,"_40":41,"_42":177,"_44":178,"_152":179,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":175,"_69":-5},{"_15":168,"_29":169,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":170,"_39":-5,"_40":41,"_42":171,"_44":172,"_152":173,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":169,"_69":-5},{"_15":162,"_29":163,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":164,"_39":-5,"_40":41,"_42":165,"_44":166,"_152":167,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":163,"_69":-5},{"_15":147,"_29":148,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":149,"_39":-5,"_40":41,"_42":150,"_44":151,"_152":153,"_51":-5,"_154":-5,"_155":-5,"_156":-5,"_60":-5,"_157":-5,"_158":-5,"_159":-5,"_160":-5,"_161":-5,"_68":148,"_69":-5},"person_A5103223832","Jingxin Qiao","{\"openalex\":\"A5103223832\",\"orcid\":\"0000-0002-8617-5148\"}","2026-05-16T14:05:55.178951858","2026-05-19T06:45:56.191823972","orcid","0000-0002-8617-5148","affiliation","researchArea","paperCount","homepage","linkedin","twitter","github","hindex","person_A5068036777","Yueshan Li","{\"openalex\":\"A5068036777\",\"orcid\":\"0000-0003-2343-1252\"}","2026-05-16T14:05:56.183734592","2026-05-19T06:45:56.199808506","0000-0003-2343-1252","person_A5101841256","Rui Zeng","{\"openalex\":\"A5101841256\",\"orcid\":\"0000-0001-9716-6354\"}","2026-05-16T14:05:57.179976711","2026-05-19T06:45:56.209363757","0000-0001-9716-6354","person_A5083092904","Feng‐Liang Liu","{\"openalex\":\"A5083092904\",\"orcid\":\"0000-0002-5038-5012\"}","2026-05-16T14:05:58.184891299","2026-05-19T06:45:56.217088119","0000-0002-5038-5012","person_A5009768750","Rong‐Hua Luo","{\"openalex\":\"A5009768750\"}","2026-05-16T14:05:59.17893841","2026-05-19T06:45:56.23056453","person_A5101458552","Chong Huang","{\"openalex\":\"A5101458552\",\"orcid\":\"0000-0003-0951-3411\"}","2026-05-16T14:06:00.195234216","2026-05-19T06:45:56.239269286","0000-0003-0951-3411","person_A5012993899","Baoxue Quan","{\"openalex\":\"A5012993899\",\"orcid\":\"0000-0002-7312-2645\"}","2026-05-16T14:06:01.194067509","2026-05-19T06:45:56.257769952","0000-0002-7312-2645","person_A5101547020","C. Shen","{\"openalex\":\"A5101547020\",\"orcid\":\"0000-0002-7521-4068\"}","2026-05-16T14:06:01.277834604","2026-05-19T06:45:56.266558193","0000-0002-7521-4068","person_A5100704584","Xinlei Liu","{\"openalex\":\"A5100704584\",\"orcid\":\"0000-0001-7216-9292\"}","2026-05-16T14:06:02.184332259","2026-05-19T06:45:56.298002083","0000-0001-7216-9292","person_A5101700729","Weining Sun","{\"openalex\":\"A5101700729\",\"orcid\":\"0000-0002-3395-7840\"}","2026-05-16T14:06:03.175842595","2026-05-19T06:45:56.343982615","0000-0002-3395-7840","person_A5052043120","Xincheng Ni","{\"openalex\":\"A5052043120\",\"orcid\":\"0000-0002-9723-4756\"}","2026-05-16T14:06:04.184205206","2026-05-19T06:45:56.37056904","0000-0002-9723-4756","person_A5048508562","Zilei Duan","{\"openalex\":\"A5048508562\",\"orcid\":\"0000-0002-3262-9685\"}","2026-05-16T14:06:06.176163642","2026-05-19T06:45:57.217542647","0000-0002-3262-9685","person_A5102774198","Wang Qu","{\"openalex\":\"A5102774198\",\"orcid\":\"0000-0003-4041-9634\"}","2026-05-16T14:06:07.179086949","2026-05-19T06:45:57.230160826","0000-0003-4041-9634","person_A5076912388","Yanghaopeng Long","{\"openalex\":\"A5076912388\"}","2026-05-16T14:06:08.182000082","2026-05-19T06:45:57.239595168","person_A5100633763","Minghua Li","{\"openalex\":\"A5100633763\",\"orcid\":\"0000-0002-2330-3771\"}","2026-05-16T14:06:09.180896634","2026-05-19T06:45:57.253762244","0000-0002-2330-3771","person_A5103249761","Ruicheng Yang","{\"openalex\":\"A5103249761\"}","2026-05-16T14:06:10.192018776","2026-05-19T06:45:57.270202692","person_A5018406968","Yangli Zhou","{\"openalex\":\"A5018406968\",\"orcid\":\"0000-0002-9800-7766\"}","2026-05-16T14:06:13.180440564","2026-05-19T06:45:57.302820977","0000-0002-9800-7766","person_A5021379417","Wenpei Li","{\"openalex\":\"A5021379417\"}","2026-05-16T14:06:14.198383715","2026-05-19T06:45:57.317383617","person_A5101519812","Pei Chen","{\"openalex\":\"A5101519812\",\"orcid\":\"0000-0002-7710-6837\"}","2026-05-16T14:06:15.177049869","2026-05-19T06:45:57.324981062","0000-0002-7710-6837","person_A5071916793","Guifeng Lin","{\"openalex\":\"A5071916793\",\"orcid\":\"0000-0002-2888-6099\"}","2026-05-16T14:06:16.207938179","2026-05-19T06:45:57.337726456","0000-0002-2888-6099","person_A5101808148","Linli Li","{\"openalex\":\"A5101808148\",\"orcid\":\"0000-0001-7743-434X\"}","2026-05-16T14:06:19.17784445","2026-05-19T06:45:57.360244457","0000-0001-7743-434X","person_A5039965800","Yiguo Hu","{\"openalex\":\"A5039965800\",\"orcid\":\"0000-0002-3973-2140\"}","2026-05-16T14:06:20.176994612","2026-05-19T06:45:57.369216006","0000-0002-3973-2140","person_A5067714177","Guangwen Lu","{\"openalex\":\"A5067714177\",\"orcid\":\"0000-0001-7568-592X\"}","2026-05-16T14:06:21.181927783","2026-05-19T06:45:57.380115049","0000-0001-7568-592X","person_A5100367602","Weimin Li","{\"openalex\":\"A5100367602\",\"orcid\":\"0000-0001-7956-1553\"}","2026-05-16T14:06:22.188065776","2026-05-19T06:45:57.388528116","0000-0001-7956-1553","person_A5090403310","Yuquan Wei","{\"openalex\":\"A5090403310\",\"orcid\":\"0000-0002-6211-3217\"}","2026-05-16T14:06:23.183616898","2026-05-19T06:45:57.397869595","0000-0002-6211-3217","person_A5076498328","Yong‐Tang Zheng","{\"openalex\":\"A5076498328\",\"orcid\":\"0000-0001-5469-0324\"}","2026-05-16T14:06:24.178595935","2026-05-19T06:45:57.405139056","0000-0001-5469-0324","person_A5071446370","Jian Lei","{\"openalex\":\"A5071446370\",\"orcid\":\"0000-0001-9326-0554\"}","2026-05-16T14:06:25.325178486","2026-05-19T06:45:57.415597526","0000-0001-9326-0554","person_A5069425796","Shengyong Yang","{\"openalex\":\"A5069425796\",\"orcid\":\"0000-0001-5147-3746\"}","2026-05-14T14:14:50.184253678","2026-05-21T17:49:27.217142837","0000-0001-5147-3746","person_A5084513850","Jing You","{\"openalex\":\"A5084513850\",\"orcid\":\"0000-0002-0152-0724\"}","2026-05-22T17:31:47.2049581","2026-05-22T17:31:47.204959919","0000-0002-0152-0724","person_A5037020492","Jun Zou","{\"openalex\":\"A5037020492\",\"orcid\":\"0000-0001-5894-7780\"}","2026-05-20T08:09:33.18475129","2026-05-20T08:09:33.184805938","0000-0001-5894-7780","person_A5003234826","Ling Xu","{\"openalex\":\"A5003234826\",\"orcid\":\"0000-0002-5040-5634\"}","2026-05-23T02:46:05.213452313","2026-05-23T02:46:05.213453954","0000-0002-5040-5634","person_A5022801548","Xiaolong Liu","{\"openalex\":\"A5022801548\",\"orcid\":\"0000-0003-1143-9951\"}","2026-05-22T06:24:41.178268076","2026-05-22T06:24:41.178269541","0000-0003-1143-9951","person_A5100365577","Yifei Wang","{\"openalex\":\"A5100365577\",\"orcid\":\"0000-0002-1314-8712\"}","2026-05-15T09:01:46.349593893","2026-05-21T06:30:16.190720096","0000-0002-1314-8712",{"_15":351,"_29":71,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":352,"_39":-5,"_40":353,"_42":354,"_44":355,"_356":357,"_358":359,"_360":-5,"_361":362,"_363":-5,"_156":-5,"_364":-5,"_68":71,"_69":-5},"tech_oa_T10211","{\"taxonomy_id\":\"tax_rd_T10211\"}","openalex_topics","2026-05-17T09:00:02.300065984","2026-05-17T09:00:02.30006876","techType","algorithm","domain","Physical Sciences","proposedYear","maturityLevel","growing","wikipediaUrl","patentCount",{"_15":391,"_29":71,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":392,"_39":-5,"_40":41,"_42":393,"_44":394,"_372":373,"_374":-5,"_375":376,"_377":395,"_379":396,"_381":94,"_382":383,"_384":94,"_385":-5,"_68":71,"_69":-5},{"_15":386,"_29":70,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":387,"_39":-5,"_40":41,"_42":388,"_44":389,"_372":373,"_374":-5,"_375":376,"_377":378,"_379":390,"_381":94,"_382":383,"_384":94,"_385":-5,"_68":70,"_69":-5},{"_15":368,"_29":72,"_31":-5,"_32":-5,"_33":-5,"_34":-5,"_35":36,"_37":369,"_39":-5,"_40":41,"_42":370,"_44":371,"_372":373,"_374":-5,"_375":376,"_377":378,"_379":380,"_381":94,"_382":383,"_384":94,"_385":-5,"_68":72,"_69":-5},"tax_rd_T10976","{\"openalex_topic\":\"T10976\"}","2026-05-15T05:17:07.24112237","2026-05-23T08:19:55.215883295","taxonomyType","RESEARCH_DOMAIN","code","level",3,"parentId","tax_rd_2725","path","Health Sciences/Medicine/Infectious Diseases/Viral gastroenteritis research and epidemiology","sortOrder","isLeaf",true,"entityCount","children","tax_rd_T10118","{\"openalex_topic\":\"T10118\"}","2026-05-14T01:04:38.211124657","2026-05-23T12:11:38.329012096","Health Sciences/Medicine/Infectious Diseases/SARS-CoV-2 and COVID-19 Research","tax_rd_T10211","{\"openalex_topic\":\"T10211\"}","2026-05-14T00:27:22.326170272","2026-05-23T12:39:51.272238225","tax_rd_1703","Physical Sciences/Computer Science/Computational Theory and Mathematics/Computational Drug Discovery Methods",{"_73":398,"_75":399},[],[400],{"_78":401,"_80":402,"_82":403,"_84":404},1780898660670,{"_87":406,"_89":90,"_91":401,"_92":-5,"_93":94,"_95":94,"_96":94,"_97":-5,"_98":-5,"_99":67,"_35":100,"_101":102},[86,405],"[\"portal\",\"industries\"]","industries",[407,408,409,410,411,412,413,414,415,416,417,418],{"_15":470,"_29":471,"_31":-5,"_32":472,"_33":473,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":422,"_42":-5,"_44":-5,"_372":423,"_374":-5,"_375":90,"_377":424,"_379":474,"_381":94,"_382":67,"_384":94,"_385":-5,"_68":471,"_69":473},{"_15":466,"_29":467,"_31":-5,"_32":-5,"_33":468,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":422,"_42":-5,"_44":-5,"_372":423,"_374":-5,"_375":90,"_377":424,"_379":469,"_381":94,"_382":67,"_384":94,"_385":-5,"_68":467,"_69":468},{"_15":460,"_29":461,"_31":-5,"_32":462,"_33":463,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":422,"_42":-5,"_44":-5,"_372":423,"_374":-5,"_375":90,"_377":424,"_379":464,"_381":94,"_382":67,"_384":94,"_385":-5,"_68":461,"_69":463},{"_15":456,"_29":457,"_31":-5,"_32":-5,"_33":458,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":422,"_42":-5,"_44":-5,"_372":423,"_374":-5,"_375":90,"_377":424,"_379":459,"_381":94,"_382":67,"_384":94,"_385":-5,"_68":457,"_69":458},{"_15":452,"_29":453,"_31":-5,"_32":-5,"_33":454,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":422,"_42":-5,"_44":-5,"_372":423,"_374":-5,"_375":90,"_377":424,"_379":455,"_381":94,"_382":67,"_384":94,"_385":-5,"_68":453,"_69":454},{"_15":446,"_29":447,"_31":-5,"_32":448,"_33":449,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":422,"_42":-5,"_44":-5,"_372":423,"_374":-5,"_375":90,"_377":424,"_379":450,"_381":94,"_382":67,"_384":94,"_385":-5,"_68":447,"_69":449},{"_15":442,"_29":443,"_31":-5,"_32":-5,"_33":444,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":422,"_42":-5,"_44":-5,"_372":423,"_374":-5,"_375":90,"_377":424,"_379":445,"_381":94,"_382":383,"_384":94,"_385":-5,"_68":443,"_69":444},{"_15":438,"_29":439,"_31":-5,"_32":-5,"_33":440,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":422,"_42":-5,"_44":-5,"_372":423,"_374":-5,"_375":90,"_377":424,"_379":441,"_381":94,"_382":67,"_384":94,"_385":-5,"_68":439,"_69":440},{"_15":434,"_29":435,"_31":-5,"_32":-5,"_33":436,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":422,"_42":-5,"_44":-5,"_372":423,"_374":-5,"_375":90,"_377":424,"_379":437,"_381":94,"_382":67,"_384":94,"_385":-5,"_68":435,"_69":436},{"_15":430,"_29":431,"_31":-5,"_32":-5,"_33":432,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":422,"_42":-5,"_44":-5,"_372":423,"_374":-5,"_375":90,"_377":424,"_379":433,"_381":94,"_382":67,"_384":94,"_385":-5,"_68":431,"_69":432},{"_15":426,"_29":427,"_31":-5,"_32":-5,"_33":428,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":422,"_42":-5,"_44":-5,"_372":423,"_374":-5,"_375":90,"_377":424,"_379":429,"_381":94,"_382":67,"_384":94,"_385":-5,"_68":427,"_69":428},{"_15":419,"_29":420,"_31":-5,"_32":-5,"_33":421,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":422,"_42":-5,"_44":-5,"_372":423,"_374":-5,"_375":90,"_377":424,"_379":425,"_381":94,"_382":67,"_384":94,"_385":-5,"_68":420,"_69":421},"tax_ind_smartphone","智能手机","Smartphone","manual","INDUSTRY","tax_ind_root","科技行业/智能手机","tax_ind_robot","机器人","Robotics","科技行业/机器人","tax_ind_wearable","智能穿戴","Smart Wearables","科技行业/智能穿戴","tax_ind_energy","新能源与智能制造","New Energy & Smart Manufacturing","科技行业/新能源与智能制造","tax_ind_biotech","生物科技","Biotech","科技行业/生物科技","tax_ind_quantum","量子计算","Quantum Computing","科技行业/量子计算","tax_ind_blockchain","区块链",[451],"Blockchain","科技行业/区块链","Web3","tax_ind_enterprise","企业软件","Enterprise Software","科技行业/企业软件","tax_ind_security","网络安全","Cybersecurity","科技行业/网络安全","tax_ind_semi","半导体",[465],"Semiconductor","科技行业/半导体","芯片","tax_ind_cloud","云计算","Cloud Computing","科技行业/云计算","tax_ind_ai","人工智能",[475,476],"Artificial Intelligence","科技行业/人工智能","AI","AI 技术","env",{"_479":24},"SITE_BASE_URL"]

SARS-CoV-2 M <sup>pro</sup> inhibitors with antiviral activity in a transgenic mouse model 论文

SARS-CoV-2 M <sup>pro</sup> inhibitors with antiviral activity in a transgenic mouse model · 作者