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Adaptive channels.","{\"openalex\":\"W30705981\",\"doi\":\"10.1016/j.heliyon.2019.e01126\"}","2026-05-23T11:48:54.202049464","2026-05-23T11:48:54.202051069","doi","10.1016/j.heliyon.2019.e01126","arxivId","openalexId","W30705981","abstractText","Stress may have negative or positive effects in dependence of its intensity (hormesis). We studied this phenomenon in Caenorhabditis elegans by applying weak or severe abiotic (cadmium, CdCl₂) and/or biotic stress (different bacterial diets) during cultivation/breeding of the worms and determining their developmental speed or survival and performing transcriptome profiling and RT-qPCR analyses to explore the genetic basis of the detected phenotypic differences. To specify weak or severe stress, developmental speed was measured at different cadmium concentrations, and survival assays were carried out on different bacterial species as feed for the worms. These studies showed that 0.1 μmol/L or 10 mmol/L of CdCl₂ were weak or severe abiotic stressors, and that E. coli HT115 or Chitinophaga arvensicola feeding can be considered as weak or severe biotic stress. Extensive phenotypic studies on wild type (WT) and different signaling mutants (e.g., kgb-1Δ and pmk-1Δ) and genetic studies on WT revealed, inter alia, the following results. WT worms bred on E. coli OP50, which is a known cause of high lipid levels in the worms, showed high resistance to severe abiotic stress and elevated gene expression for protein biosynthesis. WT worms bred under weak biotic stress (E. coli HT115 feeding which causes lower lipid levels) showed an elevated resistance to severe biotic stress, elevated gene expression for the innate immune response and signaling but reduced gene expression for protein biosynthesis. WT worms bred under weak biotic and abiotic stress (E. coli HT115 feeding plus 0.1 μmol/L of CdCl₂) showed high resistance to severe biotic stress, elevated expression of DAF-16 target genes (e.g., genes for small heat shock proteins) but further reduced gene expression for protein biosynthesis. WT worms bred under weak biotic but higher abiotic stress (E. coli HT115 feeding plus 10 μmol/L of CdCl₂) showed re-intensified gene expression for the innate immune response, signaling, and protein biosynthesis, which, however, did not caused a higher resistance to severe biotic stress. E. coli OP50 feeding as well as weak abiotic and biotic stress during incubations also improved the age-specific survival probability of adult WT worms. Thus, this study showed that a bacterial diet resulting in higher levels of energy resources in the worms (E. coli OP50 feeding) or weak abiotic and biotic stress promote the resistance to severe abiotic or biotic stress and the age-specific survival probability of WT.","publishedDate","1996-01-01","publishedYear",1996,"venue","Harvard business review",216,"authors","keywords",[127],"pdfUrl","topVenue","Neural Networks and Applications",{"_59":129,"_61":130},[],[131],{"_64":132,"_66":133,"_68":134,"_70":135},1784504002165,{"_73":137,"_75":76,"_77":132,"_78":-5,"_79":26,"_80":26,"_81":26,"_82":-5,"_83":-5,"_84":85,"_35":86,"_87":88},[72,136],"[\"portal\",\"industries\"]","industries",[138,139,140,141,142,143,144,145,146,147,148,149],{"_15":211,"_29":212,"_31":-5,"_32":213,"_33":214,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":153,"_42":-5,"_44":-5,"_154":155,"_156":-5,"_157":76,"_158":159,"_160":215,"_162":26,"_163":85,"_164":26,"_165":-5,"_57":212,"_58":214},{"_15":207,"_29":208,"_31":-5,"_32":-5,"_33":209,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":153,"_42":-5,"_44":-5,"_154":155,"_156":-5,"_157":76,"_158":159,"_160":210,"_162":26,"_163":85,"_164":26,"_165":-5,"_57":208,"_58":209},{"_15":201,"_29":202,"_31":-5,"_32":203,"_33":204,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":153,"_42":-5,"_44":-5,"_154":155,"_156":-5,"_157":76,"_158":159,"_160":205,"_162":26,"_163":85,"_164":26,"_165":-5,"_57":202,"_58":204},{"_15":197,"_29":198,"_31":-5,"_32":-5,"_33":199,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":153,"_42":-5,"_44":-5,"_154":155,"_156":-5,"_157":76,"_158":159,"_160":200,"_162":26,"_163":85,"_164":26,"_165":-5,"_57":198,"_58":199},{"_15":193,"_29":194,"_31":-5,"_32":-5,"_33":195,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":153,"_42":-5,"_44":-5,"_154":155,"_156":-5,"_157":76,"_158":159,"_160":196,"_162":26,"_163":85,"_164":26,"_165":-5,"_57":194,"_58":195},{"_15":187,"_29":188,"_31":-5,"_32":189,"_33":190,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":153,"_42":-5,"_44":-5,"_154":155,"_156":-5,"_157":76,"_158":159,"_160":191,"_162":26,"_163":85,"_164":26,"_165":-5,"_57":188,"_58":190},{"_15":182,"_29":183,"_31":-5,"_32":-5,"_33":184,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":153,"_42":-5,"_44":-5,"_154":155,"_156":-5,"_157":76,"_158":159,"_160":185,"_162":26,"_163":186,"_164":26,"_165":-5,"_57":183,"_58":184},{"_15":178,"_29":179,"_31":-5,"_32":-5,"_33":180,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":153,"_42":-5,"_44":-5,"_154":155,"_156":-5,"_157":76,"_158":159,"_160":181,"_162":26,"_163":85,"_164":26,"_165":-5,"_57":179,"_58":180},{"_15":174,"_29":175,"_31":-5,"_32":-5,"_33":176,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":153,"_42":-5,"_44":-5,"_154":155,"_156":-5,"_157":76,"_158":159,"_160":177,"_162":26,"_163":85,"_164":26,"_165":-5,"_57":175,"_58":176},{"_15":170,"_29":171,"_31":-5,"_32":-5,"_33":172,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":153,"_42":-5,"_44":-5,"_154":155,"_156":-5,"_157":76,"_158":159,"_160":173,"_162":26,"_163":85,"_164":26,"_165":-5,"_57":171,"_58":172},{"_15":166,"_29":167,"_31":-5,"_32":-5,"_33":168,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":153,"_42":-5,"_44":-5,"_154":155,"_156":-5,"_157":76,"_158":159,"_160":169,"_162":26,"_163":85,"_164":26,"_165":-5,"_57":167,"_58":168},{"_15":150,"_29":151,"_31":-5,"_32":-5,"_33":152,"_34":-5,"_35":36,"_37":-5,"_39":-5,"_40":153,"_42":-5,"_44":-5,"_154":155,"_156":-5,"_157":76,"_158":159,"_160":161,"_162":26,"_163":85,"_164":26,"_165":-5,"_57":151,"_58":152},"tax_ind_smartphone","智能手机","Smartphone","manual","taxonomyType","INDUSTRY","code","level","parentId","tax_ind_root","path","科技行业/智能手机","sortOrder","isLeaf","entityCount","children","tax_ind_robot","机器人","Robotics","科技行业/机器人","tax_ind_wearable","智能穿戴","Smart Wearables","科技行业/智能穿戴","tax_ind_energy","新能源与智能制造","New Energy & Smart Manufacturing","科技行业/新能源与智能制造","tax_ind_biotech","生物科技","Biotech","科技行业/生物科技","tax_ind_quantum","量子计算","Quantum Computing","科技行业/量子计算",true,"tax_ind_blockchain","区块链",[192],"Blockchain","科技行业/区块链","Web3","tax_ind_enterprise","企业软件","Enterprise Software","科技行业/企业软件","tax_ind_security","网络安全","Cybersecurity","科技行业/网络安全","tax_ind_semi","半导体",[206],"Semiconductor","科技行业/半导体","芯片","tax_ind_cloud","云计算","Cloud Computing","科技行业/云计算","tax_ind_ai","人工智能",[216,217],"Artificial Intelligence","科技行业/人工智能","AI","AI 技术","env",{"_220":24},"SITE_BASE_URL"]

James A. Narus 人物

James A. Narus · 相关文章