Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance论文
Nature reviews. Cancer2018引用: 217
Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment论文
Pharmacology & Therapeutics2017引用: 495
Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer论文
Clinical Breast Cancer2016引用: 264
Enhancing the Enrichment of Pharmacophore-Based Target Prediction for the Polypharmacological Profiles of Drugs论文
Journal of Chemical Information and Modeling2016引用: 283
Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts论文
Journal of Medicinal Chemistry2015引用: 247
Searching for Drug Synergy in Complex Dose–Response Landscapes Using an Interaction Potency Model论文
Computational and Structural Biotechnology Journal2015引用: 862
Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors论文
Journal of Medicinal Chemistry2014引用: 239
An International Ki67 Reproducibility Study论文
JNCI Journal of the National Cancer Institute2013引用: 595
Polypharmacology – Foe or Friend?论文
Journal of Medicinal Chemistry2013引用: 460
Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas论文
Cancer Cell2012引用: 563
The ERBB network: at last, cancer therapy meets systems biology论文
Nature reviews. Cancer2012引用: 988
Melanoma whole-exome sequencing identifies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance论文
Nature Communications2012引用: 619
Quantitative comparison of immunohistochemical staining measured by digital image analysis versus pathologist visual scoring论文
Diagnostic Pathology2012引用: 432
Polypharmacology: drug discovery for the future论文
Expert Review of Clinical Pharmacology2012引用: 470
Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein论文
Journal of Biological Chemistry2011引用: 424
Resistance to BRAF Inhibition in Melanomas论文
New England Journal of Medicine2011引用: 242
Subtype and pathway specific responses to anticancer compounds in breast cancer论文
Proceedings of the National Academy of Sciences2011引用: 503
Differential sensitivity of melanoma cell lines with BRAF V600E mutation to the specific Raf inhibitor PLX4032论文
Journal of Translational Medicine2010引用: 227
High-throughput kinase profiling as a platform for drug discovery论文
Nature Reviews Drug Discovery2008引用: 217
Recommendations for Improved Standardization of Immunohistochemistry论文
Applied immunohistochemistry & molecular morphology2007引用: 221
第 1-20 条，共 29 条
上一页下一页