foldingdiff产品(microsoft/foldingdiff)
Diffusion models of protein structure; trigonometry and attention are all you need!
Jupyter NotebookMIT★ 568
Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations论文
Journal of Chemical Theory and Computation2018引用: 265
Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones论文
Journal of Biological Chemistry2018引用: 302
The epichaperome is an integrated chaperome network that facilitates tumour survival论文
Nature2016引用: 302
D3R grand challenge 2015: Evaluation of protein–ligand pose and affinity predictions论文
Journal of Computer-Aided Molecular Design2016引用: 227
Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils论文
Molecular Cell2015引用: 417
Hsp90, an unlikely ally in the war on cancer论文
FEBS Journal2013引用: 220
An Interdomain Energetic Tug-of-War Creates the Allosterically Active State in Hsp70 Molecular Chaperones论文
Cell2012引用: 256
Hsp90: Structure and Function论文
Topics in current chemistry2012引用: 334
The Therapeutic Target Hsp90 and Cancer Hallmarks论文
Current Pharmaceutical Design2012引用: 339
Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?论文
Clinical Cancer Research2012引用: 896
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers论文
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research2011引用: 448
Ganetespib, a Unique Triazolone-Containing Hsp90 Inhibitor, Exhibits Potent Antitumor Activity and a Superior Safety Profile for Cancer Therapy论文
Molecular Cancer Therapeutics2011引用: 230
An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine论文
PLoS ONE2011引用: 260
Heat shock proteins in toxicology: How close and how far?论文
Life Sciences2010引用: 500
Withaferin A targets heat shock protein 90 in pancreatic cancer cells论文
Biochemical Pharmacology2009引用: 310
Dynamic activation of an allosteric regulatory protein论文
Nature2009引用: 384
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models论文
Proceedings of the National Academy of Sciences2009引用: 313
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90论文
Journal of Clinical Investigation2009引用: 241
The Hsp90 molecular chaperone: an open and shut case for treatment论文
Biochemical Journal2008引用: 443
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