Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models论文
Nature Reviews Drug Discovery2019引用: 244
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine论文
Nature Communications2018引用: 270
The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread论文
FEMS Microbiology Reviews2016引用: 251
Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment论文
Antimicrobial Agents and Chemotherapy2015引用: 320
Deep Learning for Drug-Induced Liver Injury论文
Journal of Chemical Information and Modeling2015引用: 382
Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network论文
American Journal of Tropical Medicine and Hygiene2015引用: 305
Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine论文
American Journal of Tropical Medicine and Hygiene2014引用: 300
Managing the challenge of chemically reactive metabolites in drug development论文
Nature Reviews Drug Discovery2011引用: 453
Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States论文
Chemical Research in Toxicology2011引用: 692
FDA-approved drug labeling for the study of drug-induced liver injury论文
Drug Discovery Today2011引用: 407
Toxicity of the antimalarial artemisinin and its dervatives论文
Critical Reviews in Toxicology2010引用: 218
Artemisinin combination therapy for vivax malaria论文
The Lancet Infectious Diseases2010引用: 222
Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury论文
Toxicological Sciences2008引用: 490
Applying Mechanisms of Chemical Toxicity to Predict Drug Safety论文
Chemical Research in Toxicology2007引用: 228
High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening论文
Archives of Toxicology2006引用: 607
Piperaquine论文
Drugs2005引用: 296
Minimising the potential for metabolic activation in drug discovery论文
Expert Opinion on Drug Metabolism & Toxicology2005引用: 231
Role of Metabolism in Drug-Induced Idiosyncratic Hepatotoxicity论文
Critical Reviews in Toxicology2005引用: 320
Effectiveness of Antimalarial Drugs论文
New England Journal of Medicine2005引用: 369
Artemisinins: mechanisms of action and potential for resistance论文
Drug Resistance Updates2004引用: 240
第 1-20 条，共 32 条
上一页下一页