Statins as Neuroprotectants: A Comparative In Vitro Study of Lipophilicity, Blood-Brain-Barrier Penetration, Lowering of Brain Cholesterol, and Decrease of Neuron Cell Death 论文

2011Journal of Alzheimer s Disease引用 246
Computational Drug Discovery MethodsLipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

摘要

There is growing evidence to support the hypothesis that statins may act as neuroprotectants in several neuropathological conditions, including Alzheimer's disease. The mechanisms for neuroprotection are only partially understood, however, and pleiot