The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal 论文
2009Journal of Neurochemistry引用 807
Alzheimer's disease research and treatmentsComputational Drug Discovery MethodsPrion Diseases and Protein Misfolding
详细信息
- 发表期刊/会议
- Journal of Neurochemistry
- 发表日期
- 2009-05-18
- 发表年份
- 2009
关键词
Alzheimer's disease research and treatmentsComputational Drug Discovery MethodsPrion Diseases and Protein Misfolding
摘要
The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer's disease. Recent clinical trials based on this hypothesis have been inconclusive. In this article I review the current status of the hypothesis and suggest that a major scientific need is to understand the normal function of amyloid-beta precursor protein (APP) and think how this may relate to the cell death in the disease process.