foldingdiff产品(microsoft/foldingdiff)
Diffusion models of protein structure; trigonometry and attention are all you need!
Jupyter NotebookMIT★ 568
ThT 101: a primer on the use of thioflavin T to investigate amyloid formation论文
Amyloid2017引用: 434
Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions论文
Cell2017引用: 248
Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils论文
Molecular Cell2015引用: 417
Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein论文
Journal of Neuroscience2010引用: 406
Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model论文
American Journal Of Pathology2010引用: 228
Alzheimer's Disease and the Amyloid-β Peptide论文
Journal of Alzheimer s Disease2010引用: 1.7K
Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils—current status论文
Journal of Chemical Biology2009引用: 646
The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal论文
Journal of Neurochemistry2009引用: 807
Structure–neurotoxicity relationships of amyloid β-protein oligomers论文
Proceedings of the National Academy of Sciences2009引用: 767
Amyloid β-Protein Assembly and Alzheimer Disease论文
Journal of Biological Chemistry2008引用: 603
Animal models of Alzheimer's disease and frontotemporal dementia论文
Nature reviews. Neuroscience2008引用: 667
Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models论文
Journal of Biological Chemistry2007引用: 408
Temporal Profile of Amyloid-β (Aβ) Oligomerization in an in Vivo Model of Alzheimer Disease论文
Journal of Biological Chemistry2005引用: 376
Novel Therapeutic Approach for the Treatment of Alzheimer's Disease by Peripheral Administration of Agents with an Affinity to β-Amyloid论文
Journal of Neuroscience2003引用: 326
Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695论文
Journal of Biological Chemistry2001引用: 952
Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease论文
Journal of Neuroscience2001引用: 1.1K
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease论文
Proceedings of the National Academy of Sciences2001引用: 1.3K
Vaccination with soluble Aβ oligomers generates toxicity‐neutralizing antibodies论文
Journal of Neurochemistry2001引用: 343
L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity论文
Biochemistry2000引用: 366
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